Steroids and derivatives
Medchemexpress LLC Prostaglandin D2 met 5mg | 49852-81-5 | 366.49 | C21H34O5 | 5 MG
Prostaglandin D2 methyl ester is a methyl-ester prodrug of prostaglandin D2 used in pharmacology and cell-based research to probe PGD2 receptor signaling. It is more lipid-soluble and cell-permeable than PGD2 and is applied to studies of DP and CRTH2 receptor pharmacology.
- Prodrug of prostaglandin D2 with increased lipid solubility and cell permeability.
- Suitable for receptor pharmacology and cell-based assays.
- Reported Ki values: mCRTH2 160 nM; mDP 175 nM; hCRTH2 460 nM; hDP 270 nM.
- Molecular formula C21H34O5; molecular weight 366.49.
- Purity 97.1%; appearance colorless to light yellow liquid.
- Packaged as a 5 mg vial (13.64 mM in 1 mL methyl acetate).
Medchemexpress LLC Fluorometholone (Standard) | 426-13-1 | MFCD00056461 | 98.8% | 5 MG
Fluorometholone (Standard) is the analytical standard of Fluorometholone, a synthetic glucocorticoid. It acts as a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic properties. This product is intended for research and analytical applications, including research on dry eye.
- Analytical standard
- Glucocorticoid receptor agonist
- Anti-inflammatory properties
- Anti-allergic properties
- Used in qualitative, quantitative and methodological research experiments
- Applications include HPLC, GC, and MS
Medchemexpress LLC Fluorometholone acetate | 3801-06-7 | 98.5% | 1 ML
Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It potently inhibits carbonic anhydrase (CA) with IC50s of 2.18 μM and 17.5 μM for hCA-I and hCA-II, respectively. It has anti-inflammatory effects and shows potential for external ocular inflammation research.
- Molecular weight of 418.50
- Chemical formula C24H31FO5
- Appears as a solid
- White to off-white color
- Soluble in DMSO at 100 mg/mL (238.95 mM)
- Store powder at -20°C for 3 years
- Store in solvent at -80°C for 6 months or -20°C for 1 month
- Potent inhibitor of carbonic anhydrase (CA)
- Exhibits anti-inflammatory effects
- Potential for external ocular inflammation research
- Ki values for hCA-I and hCA-II are 1.044 μM and 9.98 μM, respectively
- Reduced polymorphonuclear leukocytes in the cornea by an average of 47% in vivo studies
Medchemexpress LLC Fluorometholone acetate | 3801-06-7 | 98.5% | 25 MG
Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It potently inhibits carbonic anhydrase (CA) and has anti-inflammatory effects, making it suitable for external ocular inflammation research.
- Potently inhibits carbonic anhydrase (CA)
- Inhibits hCA-I with IC50 of 2.18 μM
- Inhibits hCA-II with IC50 of 17.5 μM
- Used in inflammation/immunology research
- Appears as a white to off-white solid
Medchemexpress LLC Estrone sulfate potassium | 1240-04-6 | 99.9% | 388.52 | 10 MG
Estrone sulfate potassium | 1240-04-6 | 99.9% | 388.52 | 10 MG
Medchemexpress LLC Estrone sulfate (potassium) | 1240-04-6 | 99.9% | 388.52 | 25 MG
Estrone sulfate potassium is an inactive endogenous estrogen that can be converted into Estrone and Estradiol. It is also a substrate of the OATP1B3 transporter. This compound can be converted into Estrone and Estradiol in normal mammary parenchymal cells. It stimulates the growth of nitrosomethylurea-induced mammary tumors in ovariectomized rats and the colony formation of dispersed nitrosomethylurea mammary cells, with conversion occurring both in vivo and in vitro. This product is applicable to breast cancer-related research.
- An inactive endogenous estrogen
- Substrate of the OATP1B3 transporter
- Converted to estrone and estradiol in normal mammary parenchymal cells
- Stimulates growth of nitrosomethylurea-induced mammary tumors and colony formation of dispersed nitrosomethylurea mammary cells
- Applicable to breast cancer-related research
Medchemexpress LLC Estra-1,3,5(10)-trien-17-one, 3-[(aminosulfonyl)oxy]- | 148672-09-7 | 99.99% | C18H23NO4S | 50 MG
Estrone O-sulfamate is a potent steroid sulfatase (STS) inhibitor. It exhibits inhibitory activity for STS in placental microsomes preparation and in MCF-7 cells, and can be utilized for cancer research.
- Potent steroid sulfatase (STS) inhibitor
- Exhibits inhibitory activity for STS in placental microsomes and MCF-7 cells
- Can be used for cancer research
- Shows inhibitory activity against human steroid sulfatase over-expressed in CHO cells
- Exhibits antiproliferative activity against various human cancer cell lines
- Inhibits human placental steroid sulfatase in HEK293 cells
- Inhibits estrone sulfatase in JEG-3 cells
- Causes growth inhibition and antiproliferative activity in MCF7 cells
Medchemexpress LLC Alpha-estradiol-d2 | 81586-94-9 | 99.75% | 5 MG
Alpha-Estradiol-d2 is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor used as a topical medication in the treatment of androgenic alopecia. Deuteration has gained attention due to its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
