Steroids and derivatives
Medchemexpress LLC Estradiol 17-(β-D-Glucuronide) sodium | 15087-02-2 | 98.9% | 50 MG
Estradiol 17-(β-D-Glucuronide) sodium is a D-ring glucuronide metabolite of natural estrogen formed in the liver. It functions as a substrate of the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2). This compound regulates and inhibits MRP8-mediated transport processes and can be used in studies related to intrahepatic cholestasis, as it induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis in female rats.
- Metabolite of natural estrogen
- Substrate of Oatp and Mrp2
- Regulates and inhibits MRP8-mediated transport processes
- Induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis
- Useful in studies related to intrahepatic cholestasis
- Solid, white to off-white appearance
- Molecular weight of 470.49
- Chemical formula C24H31NaO8
Medchemexpress LLC Spaglumic acid-d3 | 94.9% | 307.27 g/mol | C11H13D3N2O8 | 1mg
Spaglumic acid-d3 (N-Acetylaspartylglutamic acid-d3) is the deuterium labeled Spaglumic Acid (HY-100921) Spaglumic Acid is a neuropeptide[1]
Cayman Chemical GlycocholIc AcId 10g
A glycine-conjugated form of cholic acid; has roles in the emulsification of fats; reduces expression of the gene encoding FXR and increases expression of the genes encoding the bile acid receptors TGR5 and S1PR2 in SNU-245 cells at 1.6 μmol/ml; increases the intracellular accumulation and cytotoxicity of epirubicin in Caco-2 cells at 250 μM, as well as decreases expression of the genes encoding MDR1, MRP1, and MRP2 when used alone or in combination with epirubicin; increases absorption of epirubicin into everted sacs of rat ileum and jejunum at 250 μM; bile acid composition ratio of glycocholic acid is elevated in bile of patients with cholangiocarcinoma compared with patients with pancreatic cancer or benign biliary diseases; serum levels are elevated in patients with hepatocellular carcinoma compared with healthy individuals
Cayman Chemical 25hdrox VItamIn D3 3 3am 10mg
A vitamin D3 analog; contains a highly reactive amine group that can be coupled to a sepharose matrix for affinity purification of vitamin D binding protein; inhibits 25-hydroxy vitamin D3-1α-hydroxylase
Cayman Chemical 25hydroxy VItamIn D3 3 3am 1mg
A vitamin D3 analog; contains a highly reactive amine group that can be coupled to a sepharose matrix for affinity purification of vitamin D binding protein; inhibits 25-hydroxy vitamin D3-1α-hydroxylase
Medchemexpress LLC Estrone (Standard) | 53-16-7 | 99.7% | 50 MG
Estrone (Standard) is the analytical standard of Estrone, a natural estrogenic hormone (E1) produced by various tissues, particularly adipose tissue. It is intended for research and analytical applications, resulting from the aromatization of androstenedione in fat cells.
- Used as a reference standard assay
- Utilized in qualitative, quantitative, and methodological research experiments
- Commonly used in HPLC, GC, and MS applications
eMolecules estra-1(10),2,4-triene-3,16,17-triol | 50-27-1 | MFCD00668446 | 25mg
Oakwood Chemical | estra-1(10),2,4-triene-3,16,17-triol | 25mg | 537722281 | 373692 | | 50-27-1 | MFCD00668446 | 288.387 | C18H24O3
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Medchemexpress LLC Alpha-estradiol | 57-91-0 | MFCD00064144 | 99.9% | 272.39 | C18H24O2 | 10 MG
Alpha-estradiol (analytical standard) is a reference material intended for analytical testing and method development. It is a weak estrogen and a 5α-reductase inhibitor supplied as a high-purity solid suitable for calibration, qualitative analyses, and quantitative assays in research and laboratory workflows.
- Analytical reference standard for research and method validation.
- High stated purity for accurate calibration (99.93%).
- Supplied as a solid for convenient handling and storage.
- Available in small pack sizes appropriate for analytical use (10 mg).
- Applicable to studies of estrogenic activity and 5α-reductase inhibition.
Medchemexpress LLC U-73343 | 142878-12-4 | 99.4% | 466.66 | 10 MG
U-73343, which works as a protonophore, is an inactive analog of U-73122 and can be used as a negative control. It dose-dependently inhibits acid secretion irrespective of the stimulant. U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 μM for PLC.
- Functions as a protonophore
- Can be used as a negative control
- Inhibits acid secretion dose-dependently
Sigma Aldrich Fine Chemicals Biosciences Hydrocortisone Impurity L50MG
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Medchemexpress LLC Glycocholic acid | 475-31-0 | MFCD00065902 | 99.9% | 465.62 g/mol | C26H43NO6 | 10 MG
Glycocholic acid (Standard) is an analytical reference material of glycocholic acid intended for research and analytical applications. It provides a characterized, high-purity reference for assay calibration, method validation, and quantitative analysis.
- High purity (99.9%) suitable for analytical use.
- Molecular weight 465.62 g/mol and chemical formula C26H43NO6.
- Supplied as a 10 mg vial for small-scale analyses.
- Intended for assay development, calibration, and method validation.
- Certificate of analysis and safety data sheet available from the manufacturer.
Medchemexpress LLC D3/5-HT receptor modulator-1 | 898532-85-9 | 391.51 | 25 MG
D3/5-HT receptor modulator-1 (compound 5i) is a selective dopamine D3 receptor and 5-HT2A receptor antagonist, and a partial 5-HT1A receptor agonist. This modulator has an atypical antipsychotic profile.
- Shows Kᵢ values of 4.5 nM, 11.9 nM, and 15.3 nM for dopamine D3, 5-HT2A, and 5-HT1A receptors, respectively.
- Has low affinity for dopamine D2 receptors, 5-HT2C receptors, and hERG channels.
TARGETMOL CHEMICALS INC MEDROXYPROGESTERONE 500MG
Also available in 50 mg 100 mg 1000 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator. purity: 99%
Medchemexpress LLC (Z)-Guggulsterone | 39025-23-5 | 99.4% | 312.45 | 10 MG
(Z)-Guggulsterone is a constituent found in the Indian Ayurvedic medicinal plant Commiphora mukul. It functions by inhibiting the growth of human prostate cancer cells through apoptosis and hinders angiogenesis by suppressing the VEGF-VEGF-R2-Akt signaling pathway. It also acts as a potent FXR antagonist, reducing ACE2 expression and inhibiting SARS-CoV-2 infection. This product is intended for research use only and is not sold to patients.
- Inhibits growth of human prostate cancer cells through apoptosis
- Hinders angiogenesis by suppressing VEGF-VEGF-R2-Akt signaling
- Acts as a potent FXR antagonist
- Reduces ACE2 expression
- Inhibits SARS-CoV-2 infection
Medchemexpress LLC Hydrocortisone hemisuccinate | 2203-97-6 | MFCD00046256 | 10 MG
Hydrocortisone hemisuccinate is a steroidal glucocorticoid research reagent used as an anti-inflammatory agent in research and analytical applications. It is supplied as solids and ready-to-use solutions for reconstitution and analytical work, and is intended for research use only (not for human consumption).
- Provides a soluble hemisuccinate ester of hydrocortisone for improved water solubility.
- Suitable as an analytical standard and research reagent.
- Available as solution formats and multiple solid quantities for flexibility in experiments.
- Contains identified molecular formula and molecular weight for analytical use.